Multiple sclerosis (MS) is a chronic degenerative disease of the central nervous system that causes inflammation, muscular weakness and a loss of motor coordination. Over time, MS patients typically become permanently disabled and, in some cases, the disease can be fatal. According to the US National Multiple Sclerosis Society, about 200 people are diagnosed every week with the disease -- often striking those 20 to 40 years of age.
Reports of cannabinoids' ability to reduce MS-related symptoms such as pain, spasticity, depression, fatigue, and incontinence are plentiful in the scientific literature.[1-14] Cannabis’ efficacy is further supported in randomized placebo-controlled trials. Investigators at the University of California at San Diego report that inhaled cannabis significantly reduces objective measures of pain intensity compared to placebo in patients with MS. They concluded that "smoked cannabis was superior to placebo in reducing spasticity and pain in patients with multiple sclerosis and provided some benefit beyond currently prescribed treatment." These results were later published in the Journal of the Canadian Medical Association. Investigators concluded, "Smoked cannabis was superior to placebo in symptom and pain reduction in patients with treatment-resistant spasticity." Not surprisingly, patients with multiple sclerosis typically report engaging in cannabis therapy,[17-19] with one survey indicating that nearly one in two MS patients use it therapeutically.
Preclinical models suggest that cannabinoids may also inhibit MS progression in addition to providing symptom management. Writing in the journal Brain, investigators at the University College of London's Institute of Neurology reported that administration of the synthetic cannabinoid agonist WIN 55,212-2 provided "significant neuroprotection" in an animal model of multiple sclerosis. "The results of this study are important because they suggest that in addition to symptom management, ... cannabis may also slow the neurodegenerative processes that ultimately lead to chronic disability in multiple sclerosis and probably other disease," researchers concluded. Spanish researchers have reported similar findings, documenting that "the treatment of EAE mice with the cannabinoid agonist WIN55,512-2 reduced their neurological disability and the progression of the disease." Purified CBD has also been shown to possess an anti-apoptotic power against the neurodegenerative processes underlying MS development in animals. Clinical data reports that the administration of oral THC can boost immune function in patients with multiple sclerosis, suggesting "pro-inflammatory disease-modifying potential of cannabinoids [for] MS." Results from a 2016 trial of children with treatment-resistant MS also demonstrated that that dronabinol reduced spasticity in the majority of patients.
A small number of controlled trials suggest that cannabis therapy may slow down the clinical progression of MS in humans. Observational data from an extended open-label study of 167 multiple sclerosis patients found that use of whole plant cannabinoid extracts relieves symptoms of pain, spasticity and bladder incontinence for an extended period of treatment (mean duration of study participants was 434 days) without requiring subjects to increase their dose. Results from another two-year open label extension trial report that the administration of cannabis extracts is associated with long-term reductions in neuropathic pain in select MS patients. On average, patients in that study required fewer daily doses of the drug and reported lower median pain scores the longer they took it. These results would be unlikely in patients suffering from a progressive disease like MS unless the cannabinoid therapy was halting its progression, investigators suggested.
In recent years, health regulators in numerous countries – including Canada, Denmark, Germany, New Zealand, Spain and the United Kingdom -- have approved the prescription use of plant cannabis extracts to treat symptoms of multiple sclerosis. Longitudinal data finds that daily use of these extracts are typically effective and well-tolerated in patients, including those with treatment-resistant MS. In some instances, patients who have failed to respond to these extracts have ultimately exhibited therapeutic benefits from whole-plant cannabis.
 Kindred et al. 2017. Cannabis use in people with Parkinson’s disease and Multiple Sclerosis: A Web-based investigation. Complimentary Therapies in Medicine 33: 99-104.
 Farzaei et al. 2017. Efficacy and tolerability of phytomedicines in multiple sclerosis patients: A review. CNS Drugs 31: 867-889.
 Rog et al. 2005. Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis. Neurology 65: 812-819.
 Wade et al. 2004. Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients. Multiple Sclerosis 10: 434-441.
 Brady et al. 2004. An open-label pilot study of cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis. Multiple Sclerosis 10: 425-433.
 Vaney et al. 2004. Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study. Multiple Sclerosis 10: 417-424.
 Zajicek et al. 2003. Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis: multicentre randomized placebo-controlled trial. The Lancet 362: 1517-1526.
 Page et al. 2003. Cannabis use as described by people with multiple sclerosis [PDF]. Canadian Journal of Neurological Sciences 30: 201-205.
 Wade et al. 2003. A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms. Clinical Rehabilitation 17: 21-29.
 Consroe et al. 1997. The perceived effects of smoked cannabis on patients with multiple sclerosis. European Journal of Neurology 38: 44-48.
 Meinck et al. 1989. Effects of cannabinoids on spasticity and ataxia in multiple sclerosis. Journal of Neurology 236: 120-122.
 Ungerleider et al. 1987. Delta-9-THC in the treatment of spasticity associated with multiple sclerosis. Advances in Alcohol and Substance Abuse 7: 39-50.
 Denis Petro. 1980. Marijuana as a therapeutic agent for muscle spasm or spasticity. Psychosomatics 21: 81-85.
 Jody Corey-Bloom. 2010. Short-term effects of cannabis therapy on spasticity in multiple sclerosis. In: University of San Diego Health Sciences, Center for Medicinal Cannabis Research. Report to the Legislature and Governor of the State of California presenting findings pursuant to SB847 which created the CMCR and provided state funding.
 Corey-Bloom et al. 2012. Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial. CMAJ 10: 1143-1150.
 Clark et al. 2004. Patterns of cannabis use among patients with multiple sclerosis. Neurology 62: 2098-2010.
 Banwell et al. 2016. Attitudes to cannabis and patterns of use among Canadians with multiple sclerosis. Multiple Sclerosis and Related Disorders 10: 123-126.
 Reuters News Wire. August 19, 2002. "Marijuana helps MS patients alleviate pain, spasms."
 Pryce et al. 2003. Cannabinoids inhibit neurodegeneration in models of multiple sclerosis. Brain 126: 2191-2202.
 de Lago et al. 2012. Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice, acting preferentially through CB(1) receptor-mediated anti-inflammatory effects. Neuropharmacology 62: 2299-2308.
 Giacoppo et al. 2015. Purified cannabidiol, the main non-psychotropic component of Cannabis sativa, alone, counteracts neuronal apoptosis in experimental multiple sclerosis. European Review for Medical and Pharmacological Sciences 19: 4906-4919.
 Killestein et al. 2003. Immunomodulatory effects of orally administered cannabinoids in multiple sclerosis. Journal of Neuroimmunology 137: 140-143.
 Kuhlen et al. 2016. Effective treatment of spasticity using dronabinol in pediatric palliative care. European Journal of Pediatric Neurology 20: 898-903.
 Pryce et al. 2015. Neuroprotection in experimental autoimmune encephalomyelitis and progressive multiple sclerosis by cannabis-based cannabinoids. Journal of Neuroimmune Pharmacology 10: 281-292.
 Wade et al. 2006. Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms of multiple sclerosis. Multiple Sclerosis 12: 639-645.
 Rog et al. 2007. Oromucosal delta-9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial. Clinical Therapeutics 29: 2068-2079.
 M. Trojano. 2016. THC:CBD observational study data: Evolution of resistant MS spasticity and associated symptoms. European Neurology 75: 4-8.
 Secca et al. 2016. The use of medical-grade cannabis in patients non-responders to nabiximols. Journal of Neurological Sciences 15: 349-351.