While it is encouraging to see some, though not all, Republican candidates deferring to the principles of federalism in regard to the rising tide of public support in favor of marijuana law reform, far too many politicians in both parties continue to deny the reality that public and scientific opinion are in direct conflict with federal marijuana policy. In the 2016 Presidential race, it is inherent that the candidates from both political parties recognize that advocating for marijuana law reform is a political opportunity, not a political liability.