Paris, France: The administration of oral THC in rats suppresses sensitivity to opiate dependence, according to preclinical findings published in the June 24 issue of the journal Neuropsychopharmacology.
An international team of researchers from France and Canada assessed the impact oral THC (dronabinol) exposure in maternally deprived rats. (Rats that are deprived of their mothers immediately after birth are far more vulnerable to opiate dependence than non-deprived subjects.)
“[D]ronabinol treatment on maternally deprived rats normalized … morphine consumption and suppressed sensitivity to morphine conditioning,” researchers reported. “These findings point to the self-medication use of cannabis in subgroups of individuals subjected to adverse postnatal environment(s).”
Clinical data published this month in the July/August issue of the American Journal on Addictions reported that drug treatment subjects who used cannabis intermittently were more likely to adhere to treatment for opioid dependence.
Commenting on the studies, NORML Deputy Director Paul Armentano said, “These findings undermine the notion that cannabis is a so-called ‘gateway’ to hard drug use. Rather, these results indicate that in certain populations marijuana may be a useful tool for deterring the initiation or continuation of hard drug abuse.”
For more information, please contact Paul Armentano, NORML Deputy Director, at: paul@norml.org. Full text of the study, “Adolescent exposure to delta-9-THC blocks opiate dependence in maternally deprived rats,” appears in Psychopharmacology.