Edmonton, Canada: Food intake prior to the administration of oral THC influences drug duration and drug effect, according to clinical trial data published in the journal Cannabis and Cannabinoid Research.
Canadian researchers assessed the absorption patterns and effects of oral THC capsules in 28 subjects under either a fasted condition or after a high-fat meal.
Investigators reported that consuming a high-fat meal prior to oral THC dosing resulting in delayed drug onset, but enhanced overall drug effects.
"Altogether, these findings suggest that the presence of a high-fat meal before administrating an oral dose of THC increases the levels of both THC and 11-OH-THC, but the rate at which this occurs is slower," authors wrote. Overall, they acknowledged that oral doses of THC were "well-tolerated" by subjects in either fed or fasted states.
Authors also identified higher THC plasma levels in female subjects than in male subjects. However, they theorized that these differences may be attributable to "weight differences between [the] male and female participants and not solely the result of sex difference."
Full text of the study, "Human pharmacokinetic parameters of orally administered delta-9-tetrahydrocannabinol capsules are altered by fed versus fasted conditions and sex differences," appears in Cannabis and Cannabinoid Research.