Valencia, Spain: CBD administration is associated with behavioral changes in mice that are associated with reductions in drug-seeking behavior, according to preclinical data published in the journal Progress in Neuropsychopharmacology & Biological Psychiatry.
A team of Spanish investigators assessed the potential of CBD to modify behaviors in mice co-administered cocaine. Researchers determined, “Our data suggest that CBD can prevent the development of cocaine addiction, and, when administered during cocaine abstinence, may be of help in avoiding relapse to drug-seeking and in ameliorating the memory disturbances provoked by chronic consumption of cocaine.”
Human trials assessing the use of either cannabis or cannabinoids in cocaine-dependent subjects have yielded inconsistent results. A pair of longitudinal trials from Brazil and Canada reported that the use of cannabis was associated with the decreased use of crack cocaine in dependent subjects. By contrast, a more recent study – published earlier this year in the journal Addiction – reported that the daily administration of CBD failed to reduce cocaine cravings any better than placebo in subjects with a history of moderate to severe cocaine abuse.
Full text of the study, “Cannabidiol prevents several of the behavioral alterations related to cocaine addiction in mice,” appears in Progress in Neuropsychopharmacology & Biological Psychiatry.