San Diego, CA: The daily administration of low doses of CBD (15 mgs) improves sleep quality in patients with a history of sleep disturbances, according to clinical trial data published in the Journal of the American Nutrition Association.
A team of investigators affiliated with UCLA and the Scripps Clinic Sleep Center in San Diego assessed the efficacy of various formulations of CBD versus melatonin on sleep quality in a cohort of nearly 1,800 adults.
They reported that the use of CBD, either alone or in combination with other minor cannabinoids (e.g., cannabichromene and cannabinol), improved patients’ sleep quality in a manner similar to but which did not exceed that of melatonin. They also reported no significant differences in outcomes among those patients who consumed CBD and other cannabinoids concurrently versus those who consumed CBD alone. All CBD formulations “exhibited a favorable safety profile.”
The study’s authors concluded: “Most participants across all formulations experienced a clinically important improvement in their sleep quality. … Our findings suggest that chronic use of a low dose of CBD is safe and could improve sleep quality, though these effects do not exceed that of 5 mg melatonin.”
Other studies have previously shown that the administration of either CBD alone or the combined use of CBD and melatonin improves sleep quality in patients with insomnia. Ecological studies have reported a decline in the sales of over-the-counter sleep aids following the adoption of state-level cannabis legalization.
Full text of the study, “The safety and comparative effectiveness of non-psychoactive cannabinoid formulations for the improvement of sleep: A double-blinded, randomized controlled trial’ appears in the Journal of the American Nutrition Association.