The administration of THC modulates emotional processing in healthy volunteers, according to placebo-controlled crossover trial data published online by the journal European Neuropsychopharmacology. Researchers concluded: “These results indicate that THC administration reduces the negative bias in emotional processing. This adds human evidence to support the hypothesis that the endocannabinoid system is involved in modulation of emotional processing. Our findings also suggest a possible role for the endocannabinoid system in abnormal emotional processing, and may thus be relevant for psychiatric disorders such as major depression.”